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N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone

Laurocapram

CAS: 59227-89-3

Molecular Formula: C18H35NO

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N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Names and Identifiers

Name Laurocapram
Synonyms n0252
Azone
tranzone
Lauocapram
Laurocapram
acecloguanosine
Azone, Laurocapram
n-lauryl caprolactam
1-dodecylazepan-2-one
1-tridecylpiperidin-2-one
DODECYLAZACYCLOHEPTAN-2-ONE
1-dodecylazacycloheptan-2-one
1-n-Dodecylazacycloneptan-2-one
hexahydro-n-lauryl-2h-azepin-2-on
1-dodecylhexahydro-2h-azepin-2-one
1-Dodecylhexahydro-1H-azepine-2-one
N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
CAS 59227-89-3
EINECS 261-668-9
InChI InChI=1/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-13-16-19-17-14-12-15-18(19)20/h2-17H2,1H3

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Physico-chemical Properties

Molecular FormulaC18H35NO
Molar Mass281.48
Density0.906-0.926
Melting Point-7°
Boling Pointbp50m 160°
Flash Point164.62°C
Solubility Insoluble in water, forms an emulsion with water, and is easily soluble in various organic solvents.
Vapor Presure0mmHg at 25°C
AppearanceColorless or yellowish transparent liquid
ColorColourless
Merck14,5385
pKa-0.43±0.20(Predicted)
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.470-1.473
MDLMFCD00190580
Physical and Chemical Properties

colorless to yellowish liquid, odorless and tasteless
solubility insoluble in water, soluble in ethanol, ether, acetone and benzene

UseUsed as osmotic agent, used for all kinds of cream and hair supplies in cosmetics; Used as a penetration enhancer for topical application and massage; Used for pesticides, as a plant growth regulator and a penetration enhancer for sterilization and insecticide; In addition, it can also be used as a coloring accelerator in the fields of leather and printing and dyeing.

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
RTECSCM3995000
HS Code29339900
ToxicityLD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Upstream Downstream Industry

Raw Materialsepsilon-Caprolactam

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Reference

Reference
Show more
1. Liang Jun, Wu Huichao, du Shouying, et al. Study on percutaneous permeability of main components of baimai ointment in vitro [J]. Chinese Journal of Traditional Chinese Materia Medica, 2019, 26 (12).

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Standard

Authoritative Data Verified Data

This product is 1-dodecyl-hexahydro-2h-nitrogen weed -2-one. Ci8H3SNO shall be 97.0%-102.0%.

Last Update：2024-01-02 23:10:35

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Trait

Authoritative Data Verified Data
  • This product is colorless and transparent viscous liquid; Almost odorless, tasteless.
  • This product is highly soluble in anhydrous ethanol, ethyl acetate, ether, benzene and cyclohexane, and is insoluble in water.

relative density

The relative density of this product (General 0601) is 0. 906~926.

refractive index

The refractive index of this product (General 0622) is 1. 470~473.

viscosity

The kinematic viscosity of this product (General rule 0633 first method% capillary inner diameter 1-2mm ± 0. 05mm), 32~34 mm2/ s at 25°C.

Last Update：2022-01-01 11:21:09

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Introduction

Azone is a new type of high-efficiency, safe and non-toxic transdermal absorption enhancer, which has obvious transdermal penetration effect on hydrophilic and oleophilic drugs.
Last Update：2022-10-16 17:26:45

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Differential diagnosis

Authoritative Data Verified Data
  1. Take 2 m l of this product, add methylated 2 m l, add lm o l/L hydroxylamine hydrochloride solution (new) lm l, add 1 small capsule of potassium hydroxide, put it on a water bath for heating and let it cool. Add 1 drop of ferric chloride solution, shake well, and heat it on the water bath.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 48).
Last Update：2022-01-01 11:21:10

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Exam

Authoritative Data Verified Data

pH

take 5 m l of this product, add 5ml neutral ethanol, warm to dissolve, let cool, the solution should be neutral reaction when it meets litmus test paper.

caprolactam and related substances

take about 0.5g of this product, put it in a 10ml measuring flask, add an appropriate amount of methanol, shake to dissolve and dilute to the scale, shake well, as a test solution. In addition, an appropriate amount of caprolactam was accurately weighed, dissolved and diluted with methanol to prepare a solution containing 0.05mg per 1m l as a reference solution. According to the test for determination of residual solvents (General 0861 second method), a capillary column with 100% dimethylpolysiloxane (or similar polarity) as stationary liquid, starting at 1 0 0 1, maintained for 1 min at 15X per minute: the temperature was raised to 2 4 0 1, and the retention time of the main peak was 2 times; The detector temperature was 3 0 0 "C; The sample inlet temperature was 2 5 0 1. Take the reference solution 1m injection human gas chromatograph, adjust the detection sensitivity, so that the peak height of the main component chromatographic peak is about 25% of the full scale, the sample solution and the reference solution are respectively injected into the human gas chromatograph to record the chromatogram. If there are impurity peaks in the chromatogram of the sample solution, the Peak area of the impurity peak consistent with the retention time of caprolactam should not be greater than the main peak area of the control solution (0. 1% ), other impurity peaks are calculated by area normalization method, and a single impurity shall not exceed 1 .5%, total impurities should not be over 3 .0%.

bromide

take this product l .O g, add 1 0 m l of water, fully shake, add 3 drops of hydrochloric acid and three gas methane lm l, add 2% gas amine T solution Dropwise while shaking (new preparation is needed) 3 drops, three gas methane layer such as color, with the standard potassium bromide solution (precision weighing at 1051C dry to constant weight of potassium bromide 0. 1489G, add water to dissolve into 1 0 M l, shake well) 1.0, compared with the control solution made by the same method, not deeper (0. 1%).

ignition residue

take 0841g of this product and check it according to law (general rule). The remaining residue shall not exceed.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Last Update：2022-01-01 11:21:10

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Content determination

Authoritative Data Verified Data

measured by gas chromatography (General 0521).

chromatographic conditions and system suitability test

use 100% dimethyl polysiloxane (or polar similar) as the stationary liquid capillary column, the initial temperature is 100X:, maintain 1 min, 1 5 1 per minute to 2 4 0 1, maintain 45 minutes; The detector temperature is 300t;; The sample inlet temperature is 25 0 t. The number of theoretical plates shall be calculated according to the peak of azone, and shall not be less than 10 000. The degree of separation between the peak of azone and the peak of internal standard substance shall meet the requirements.

correction factor measurement

an appropriate amount of eicosane was taken, dissolved with n-hexane and diluted to a solution containing 2mg per 1 μl as an internal standard solution. Take another 20 m g of the reference compound of laurocapram ketone, weigh it accurately, put it in a 10ml measuring flask, dissolve it with internal standard solution, dilute it to the standard, and shake it well, l f I l was injected into the gas chromatograph and the correction factor was calculated.

assay

take about 20 m g of this product, accurately weigh it, put it in a 10ml measuring flask, dissolve it with internal standard solution and dilute it to the scale, shake it well, and inject 1 /il into the gas chromatograph. Determination, calculated according to the internal standard method, that is.

Last Update：2022-01-01 11:21:11

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Category

Authoritative Data Verified Data

pharmaceutical excipients, penetration enhancers.

Last Update：2022-01-01 11:21:11

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:21:12

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone - Reference Information

, azone, chemical name for 1-N-dodecyl Nitrogen heterocycle heptan-2-one, is a new type of efficient and safe penetration enhancers, colorless and odorless transparent liquid at room temperature, slightly viscous, odorless. It forms an emulsion with water, is soluble in various organic solvents, has good lubricity, and can promote the activity of hydrophilic and lipophilic pharmaceutical products or the penetration of nutrients in cosmetics into the skin, greatly shorten the retention time of drugs in the stratum corneum, significantly enhance the efficacy of drugs and the use of cosmetics, so it can reduce the amount of main drugs, reduce costs. The transdermal absorption of azone was delayed.
azone has obvious transdermal penetration effect on hydrophilic and lipophilic drugs, and has good penetration effect in emulsion state or colloid state, alkaloid effect is particularly obvious. The penetration enhancing effect was stronger than that of dimethyl sulfoxide, and the penetration enhancing effect of 1% azone on 8-bromo cyclic nucleotide was 12 times that of 50% dimethyl sulfoxide. Often combined with propylene glycol, produce synergistic effect, the best use of transdermal concentration of 0.1% ~ 5%, safe, low toxicity, no irritation. The chemical properties are stable, and can be stored in the dark at room temperature for more than four years.
This product can be considered as a complex of decyl methyl sulfoxide and pyrrolidone. It is a good new type of transdermal enhancer, with little skin irritation, and can promote corticosteroids, indomethacin, fluorouracil, transdermal absorption of many drugs, such as hydroquinone, The drug penetrates the skin barrier, increases local and systemic blood concentrations, and improves the bioavailability of the preparation. Both lipophilic and hydrophilic drugs have transdermal effects. And can make the keratin softening, enhance its permeability. There are anti-inflammatory, analgesic and antipruritic effects. Low toxicity of azone, oral LD50>7 g/kg, should not be combined with strong acid or Vaseline, so as not to reduce the efficacy.
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Introduction laurocapram is a new skin penetrant first reported by Stoughton, its chemical name is 1-n-dodecylazacycloheptan-2-one. Short for azone. At room temperature, azone is a colorless, tasteless, non-toxic and non-irritating oily transparent liquid with lubricity, easy coating and strong permeability. It is also a widely used organic chemicals, as well as its efficient penetration, non-toxic safety and other characteristics have attracted more and more attention, hydrophobic compounds all have the effect of enhancing penetration.
Application It is mainly used in the fields of medicine, pesticide, cosmetics, printing and dyeing, leather making, petroleum and chemical fiber, china has done a lot of fruitful work on its production and application, and its application areas are gradually expanding. The consumption of azone now is increasing at a rate of 50%, the industrialization of azone has broad prospects.
as an efficient skin penetration enhancer and a new type of non-ionic surfactant, laurocapram has been widely used in the pharmaceutical, chemical, pesticide, printing and dyeing, chemical fiber, leather and other industries, the use of the effect is very significant, more new applications are still expanding.
preparation solid-liquid phase transfer catalysis method: This method uses KOH-K2CO3 double alkali instead of potassium hydroxide or sodium hydroxide as the proton removal agent, tetrabutyl sodium bromide or polyethylene glycol is the phase transfer catalyst. Caprolactam and bromododecane were reacted in toluene or ethane solvent to form azone in one step, and the yield was over 93%. The reaction conditions are mild, without N 2 protection, easy to operate, but to be carried out in a non-aqueous solvent, is currently widely used in the domestic production of azone production process.
penetration enhancers
safe it is proved to be non-toxic and non-irritating by sub-acute toxicity, skin and damaged skin irritation, sensitization, teratogenicity and other experiments, no side effects, no irritation to the domestic eye experiment.
Use is used as an osmotic agent for various creams and hair supplies in cosmetics, as a penetration enhancer for topical application and massage; it can be used as a pesticide, as a plant growth regulator and a penetration enhancer for sterilization and pesticides. In addition, it can also be used as a coloring promoter in the field of leather and printing and dyeing.
colorless to yellowish clear oily liquid
azone is a new type of efficient, safe and non-toxic transdermal absorption enhancer, which has obvious transdermal penetration effect on hydrophilic and lipophilic drugs. Can be widely used in medicine, cosmetics, pesticides, aerosol, printing and dyeing and oil exploration and other industries, this product has strong penetration, colorless, tasteless, non-toxic, non-irritating and other advantages.
used as a highly effective skin penetration enhancer, for external use, cosmetics and as a surfactant
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-10 22:29:15
N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
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Mobile: 18000738807
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Mobile: 86+18627766980
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Mobile: 15335994747
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Wechat: A2020071098
JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Laurocapram Request for quotation
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Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
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Nantong Reform Petro-Chemical CO., LTD.
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Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Laurocapram Visit Supplier Webpage Request for quotation
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
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Guangzhou Yuanda New Material Co.,Ltd
Product Name: Laurocapram Request for quotation
CAS: 59227-89-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Laurocapram Request for quotation
CAS: 59227-89-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Laurocapram Visit Supplier Webpage Request for quotation
CAS: 59227-89-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Zouping Mingxing Chemical Co., Ltd.
Product Name: Laurocapram Request for quotation
CAS: 59227-89-3
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
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N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
Raw Materials for N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
epsilon-Caprolactam
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